patmedfarПациентоориентированная медицина и фармацияPatient-Oriented Medicine and Pharmacy2949-1924LLC Izdatelstvo OKI10.37489/2949-1924-0051ITWMRTpatmedfar-87Research ArticleУРОЛОГИЯUROLOGYIgM-нефропатия на фоне лимфомы Ходжкина: клинический случай и обзор литературыIgM nephropathy on the background of Hodgkin's lymphoma: clinical case and literature reviewhttps://orcid.org/0000-0002-2062-0421ШормановИ. С.ShormanovI. S.

Шорманов Игорь Сергеевич — д. м. н., профессор, зав. кафедрой урологии с нефрологией

Ярославль

Igor S. Shormanov — Doctor of Medical Sciences, Professor, Head. Department of Urology with Nephrology

Yaroslavl

i-s-shormanov@yandex.ruhttps://orcid.org/0000-0003-2464-572XЖигаловС. А.ZhigalovS. A.

Жигалов Сергей Алексеевич — к. м. н., доцент кафедры урологии с нефрологией

Ярославль

Sergey A. Zhigalov — Candidate of Medical Sciences, Associate Professor, Department of Urology and Nephrology

Yaroslavl

sergey.zhigalow@gmail.comhttps://orcid.org/0000-0001-5612-3227СоловьёвА. С.SolovyovA. S.

Соловьёв Андрей Сергеевич — к. м. н., доцент кафедры урологии с нефрологией

Ярославль

Andrey S. Solovyov — Candidate of Medical Sciences, Associate Professor, Department of Urology with Nephrology

Yaroslavl

a-s-soloviev89@yandex.ruБажинаО. В.BazhinaO. V.

Бажина Ольга Викторовна — к. м. н., доцент кафедры урологии с нефрологией

Ярославль

РИНЦ AuthorID: 266698

Olga V. Bazhina — Candidate of Medical Sciences, Associate Professor, Department of Urology with Nephrology

Yaroslavl

RSCI AuthorID: 266698 

https://orcid.org/0009-0005-1043-806XГороховИ. А.GorokhovI. A.

Горохов Иван Алексеевич — студент 5 курса

Ярославль

Ivan A. Gorokhov — 5th year student

Yaroslavl

ФГБОУ ВО «Ярославский государственный медицинский университет» Министерства здравоохранения Российской ФедерацииРоссияYaroslavl State Medical UniversityRussian Federation202423052024225864Copyright © Шорманов И.С., Жигалов С.А., Соловьёв А.С., Бажина О.В., Горохов И.А., 20242024Шорманов И.С., Жигалов С.А., Соловьёв А.С., Бажина О.В., Горохов И.А.Shormanov I.S., Zhigalov S.A., Solovyov A.S., Bazhina O.V., Gorokhov I.A.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.pomph.ru/jour/article/view/87

IgM-нефропатия, хотя и является редким и спорным заболеванием, привлекает внимание как морфологов, так и клиницистов. Вопросы этиопатогенеза, эпидемиологии и лечения этой патологии в настоящее время недостаточно изучены. Разнообразные морфологические проявления при световой микроскопии делают иммунофлюоресцентное исследование решающим для диагностики. Хотя IgM-нефропатия имеет общие клинико-морфологические признаки с формой болезни минимальных изменений и фокально-сегментарным гломерулосклерозом, у неё есть свои особенности, которые не все учёные признают достаточными для отнесения её к отдельной нозологической форме. Необходимо согласование морфологических критериев для диагностики IgM-нефропатии. Уточнение патогенетических механизмов развития этого заболевания поможет определить место IgM-нефропатии среди первичных гломерулопатий. Представлен редкий случай ассоциации IgM-нефропатии и лимфомы Ходжкина.

IgM nephropathy, although a rare and controversial disease, attracts the attention of both morphologists and clinicians. The issues of etiopathogenesis, epidemiology and treatment of this pathology are currently insufficiently studied. A variety of morphological manifestations under light microscopy make immunofluorescence examination crucial for diagnosis. Although IgM nephropathy shares clinical and morphological features with minimal change disease and focal segmental glomerulosclerosis, it has its own characteristics that not all scientists recognize as sufficient to classify it as a separate nosological form. It is necessary to coordinate morphological criteria for the diagnosis of IgM nephropathy. Clarifying the pathogenetic mechanisms of the development of this disease will help determine the place of IgM nephropathy among primary glomerulopathies. A rare case of association of IgM nephropathy and Hodgkin's lymphoma is presented.

IgM-нефропатиялимфома Ходжкинапервичные гломерулопатииболезнь минимальных измененийфокально-сегментарный гломерулосклерозIgM nephropathyHodgkin lymphomaprimary glomerulopathiesminimal change diseasefocal segmental glomerulosclerosisReferencesCohen AH, Border WA, Glassock RJ. Nehprotic syndrome with glomerular mesangial IgM deposits. Lab Invest. 1978 May;38(5):610-9.Cohen AH, Border WA, Glassock RJ. Nehprotic syndrome with glomerular mesangial IgM deposits. Lab Invest. 1978 May;38(5):610-9.Bhasin HK, Abuelo JG, Nayak R, Esparza AR. Mesangial proliferative glomerulonephritis. Lab Invest. 1978 Jul;39(1):21-9.Bhasin HK, Abuelo JG, Nayak R, Esparza AR. Mesangial proliferative glomerulonephritis. Lab Invest. 1978 Jul;39(1):21-9.van de Putte LB, de la Riviere GB, van Breda Vriesman PJ. Recurrent or persistent hematuria. Sign of mesangial immune-complex deposition. N Engl J Med. 1974 May 23;290(21):1165-70.van de Putte LB, de la Riviere GB, van Breda Vriesman PJ. Recurrent or persistent hematuria. Sign of mesangial immune-complex deposition. N Engl J Med. 1974 May 23;290(21):1165-70.Hsu HC, Chen WY, Lin GJ, Chen L, Kao SL, Huang CC, Lin CY. Clinical and immunopathologic study of mesangial IgM nephropathy: report of 41 cases. Histopathology. 1984 May;8(3):435-46.Hsu HC, Chen WY, Lin GJ, Chen L, Kao SL, Huang CC, Lin CY. Clinical and immunopathologic study of mesangial IgM nephropathy: report of 41 cases. Histopathology. 1984 May;8(3):435-46.Mampaso F, Gonzalo A, Teruel J, Losada M, Gallego N, Ortuno J, Bellas C. Mesangial deposits of IgM in patients with the nephrotic syndrome. ClinNephrol. 1981 Nov;16(5):230-4.Mampaso F, Gonzalo A, Teruel J, Losada M, Gallego N, Ortuno J, Bellas C. Mesangial deposits of IgM in patients with the nephrotic syndrome. ClinNephrol. 1981 Nov;16(5):230-4.Mubarak M, Kazi JI. IgM nephropathy revisited. Nephrourol Mon. 2012 Fall;4(4):603-8. doi: 10.5812/numonthly.2805.Mubarak M, Kazi JI. IgM nephropathy revisited. Nephrourol Mon. 2012 Fall;4(4):603-8. doi: 10.5812/numonthly.2805.Cavallo T, Johnson MP. Immunopathologic study of minimal change glomerular disease with mesangial IgM deposits. Nephron. 1981;27(6):281-4.Cavallo T, Johnson MP. Immunopathologic study of minimal change glomerular disease with mesangial IgM deposits. Nephron. 1981;27(6):281-4.Disciullo SO, Abuelo JG, Moalli K, Pezzullo JC. Circulating heavy IgM in IgM nephropathy. Clin Exp Immunol. 1988 Sep;73(3):395-400.Disciullo SO, Abuelo JG, Moalli K, Pezzullo JC. Circulating heavy IgM in IgM nephropathy. Clin Exp Immunol. 1988 Sep;73(3):395-400.Lawler W, Williams G, Tarpey P, Mallick NP. IgM associated primary diffuse mesangial proliferative glomerulonephritis. J Clin Pathol. 1980 Nov;33(11):1029-38.Lawler W, Williams G, Tarpey P, Mallick NP. IgM associated primary diffuse mesangial proliferative glomerulonephritis. J Clin Pathol. 1980 Nov;33(11):1029-38.Kishimoto H, Arakawa M. Clinico-pathological characterization of mesangial proliferative glomerulonephritis with predominant deposition of IgM. ClinExpNephrol.1999;3(2):110–5. doi: 10.1007/s101570050019.Kishimoto H, Arakawa M. Clinico-pathological characterization of mesangial proliferative glomerulonephritis with predominant deposition of IgM. ClinExpNephrol.1999;3(2):110–5. doi: 10.1007/s101570050019.Mubarak M, Kazi JI, Shakeel S, Lanewala A, Hashmi S, Akhter F. Clinicopathologic characteristics and steroid response of IgM nephropathy in children presenting with idiopathic nephrotic syndrome. APMIS. 2011 Mar;119(3):180-6. doi: 10.1111/j.1600-0463.2010.02708.x.Mubarak M, Kazi JI, Shakeel S, Lanewala A, Hashmi S, Akhter F. Clinicopathologic characteristics and steroid response of IgM nephropathy in children presenting with idiopathic nephrotic syndrome. APMIS. 2011 Mar;119(3):180-6. doi: 10.1111/j.1600-0463.2010.02708.x.Myllymäki J, Saha H, Mustonen J, Helin H, Pasternack A. IgM nephropathy: clinical picture and long-term prognosis. Am J Kidney Dis. 2003 Feb;41(2):343-50.Myllymäki J, Saha H, Mustonen J, Helin H, Pasternack A. IgM nephropathy: clinical picture and long-term prognosis. Am J Kidney Dis. 2003 Feb;41(2):343-50.Zeis PM, Kavazarakis E, Nakopoulou L, Moustaki M, Messaritaki A, Zeis MP, Nicolaidou P. Glomerulopathy with mesangialIgM deposits: longterm follow up of 64 children. Pediatr Int. 2001 Jun;43(3):287-92.Zeis PM, Kavazarakis E, Nakopoulou L, Moustaki M, Messaritaki A, Zeis MP, Nicolaidou P. Glomerulopathy with mesangialIgM deposits: longterm follow up of 64 children. Pediatr Int. 2001 Jun;43(3):287-92.Mokhtar GA. IgM nephropathy: clinical picture and pathological findings in 36 patients. Saudi J Kidney Dis Transpl. 2011 Sep;22(5):969-75.Mokhtar GA. IgM nephropathy: clinical picture and pathological findings in 36 patients. Saudi J Kidney Dis Transpl. 2011 Sep;22(5):969-75.Singhai AM, Vanikar AV, Goplani KR, Kanodia KV, Patel RD, Suthar KS, Patel HV, Gumber MR, Shah PR, Trivedi HL. Immunoglobulin M nephropathy nephropathy in adults and adolescents in India: a single-center study of natural history. Indian J PatholMicrobiol. 2011 Jan-Mar;54(1):3-6. doi: 10.4103/0377-4929.77315. 16. Border WA. Distinguishing minimal-change disease from mesangial disorders. Kidney Int. 1988 Sep;34(3):419-34. 17. Hamed RM. Clinical significance and long-term evolution of mesangial proliferative IgM nephropathy among Jordanian children. Ann Saudi Med. 2003 Sep-Oct;23(5):323-7.Singhai AM, Vanikar AV, Goplani KR, Kanodia KV, Patel RD, Suthar KS, Patel HV, Gumber MR, Shah PR, Trivedi HL. Immunoglobulin M nephropathy nephropathy in adults and adolescents in India: a single-center study of natural history. Indian J PatholMicrobiol. 2011 Jan-Mar;54(1):3-6. doi: 10.4103/0377-4929.77315. 16. Border WA. Distinguishing minimal-change disease from mesangial disorders. Kidney Int. 1988 Sep;34(3):419-34. 17. Hamed RM. Clinical significance and long-term evolution of mesangial proliferative IgM nephropathy among Jordanian children. Ann Saudi Med. 2003 Sep-Oct;23(5):323-7.Mubarak M, Naqvi R, Kazi J, Shakeel S. Immunoglobulin M nephropathy in adults: a clinicopathological study. Iran J Kidney Dis. 2013 May 21;7(3):214-9.Mubarak M, Naqvi R, Kazi J, Shakeel S. Immunoglobulin M nephropathy in adults: a clinicopathological study. Iran J Kidney Dis. 2013 May 21;7(3):214-9.Strassheim D, Renner B, Panzer S, Fuquay R, Kulik L, Ljubanović D, Holers VM, Thurman JM. IgM contributes to glomerular injury in FSGS. J Am SocNephrol. 2013 Feb;24(3):393-406. doi: 10.1681/ASN.2012020187.Strassheim D, Renner B, Panzer S, Fuquay R, Kulik L, Ljubanović D, Holers VM, Thurman JM. IgM contributes to glomerular injury in FSGS. J Am SocNephrol. 2013 Feb;24(3):393-406. doi: 10.1681/ASN.2012020187.Mokhtar GA. IgM nephropathy: clinical picture and pathological findings in 36 patients. Saudi J Kidney Dis Transpl. 2011 Sep;22(5):969-75.Mokhtar GA. IgM nephropathy: clinical picture and pathological findings in 36 patients. Saudi J Kidney Dis Transpl. 2011 Sep;22(5):969-75.Swartz SJ, Eldin KW, Hicks MJ, Feig DI. Minimal change disease with IgM+ immunofluorescence: a subtype of nephrotic syndrome. PediatrNephrol. 2009 Jun;24(6):1187-92. doi: 10.1007/s00467-009-1130-0.Swartz SJ, Eldin KW, Hicks MJ, Feig DI. Minimal change disease with IgM+ immunofluorescence: a subtype of nephrotic syndrome. PediatrNephrol. 2009 Jun;24(6):1187-92. doi: 10.1007/s00467-009-1130-0.Bhowmik D, Chitale A, Bulchand S. IgM nephropathy in adults: incidence and correlation with electron microscopic features. Indian J PatholMicrobiol. 2007 Jul;50(3):511-4.Bhowmik D, Chitale A, Bulchand S. IgM nephropathy in adults: incidence and correlation with electron microscopic features. Indian J PatholMicrobiol. 2007 Jul;50(3):511-4.Maruyama M, Toyoda M, Umezono T, Miyauchi M, Yamamoto N, Kimura M, Honma M, Nishina M, Endoh M, Sakai H, Suzuki D. [Clinical significance of IgM deposition in the mesangium and mesangialhypercellularity in adult minimal change nephrotic syndrome]. Nihon JinzoGakkai Shi. 2006;48(1):14-21.Maruyama M, Toyoda M, Umezono T, Miyauchi M, Yamamoto N, Kimura M, Honma M, Nishina M, Endoh M, Sakai H, Suzuki D. [Clinical significance of IgM deposition in the mesangium and mesangialhypercellularity in adult minimal change nephrotic syndrome]. Nihon JinzoGakkai Shi. 2006;48(1):14-21.Al-Eisa A, Carter JE, Lirenman DS, Magil AB. Childhood IgM nephropathy: comparison with minimal change disease. Nephron. 1996;72(1):37-43.Al-Eisa A, Carter JE, Lirenman DS, Magil AB. Childhood IgM nephropathy: comparison with minimal change disease. Nephron. 1996;72(1):37-43.Routledge RC, Hann IM, Jones PH. Hodgkin's disease complicated by the nephrotic syndrome. Cancer. 1976 Oct;38(4):1735-40.Routledge RC, Hann IM, Jones PH. Hodgkin's disease complicated by the nephrotic syndrome. Cancer. 1976 Oct;38(4):1735-40.Rault R, Holley JL, Banner BF, el-Shahawy M. Glomerulonephritis and non-Hodgkin's lymphoma: a report of two cases and review of the literature. Am J Kidney Dis. 1992 Jul;20(1):84-9.Rault R, Holley JL, Banner BF, el-Shahawy M. Glomerulonephritis and non-Hodgkin's lymphoma: a report of two cases and review of the literature. Am J Kidney Dis. 1992 Jul;20(1):84-9.Захарова Е.В., Столяревич Е.С., Виноградова О.В., др. Поражения почек при лимфоплазмоцитарных заболеваниях (обзор литературы и клинические наблюдения). Нефрология и диализ. 2009;11(2):68-94.Захарова Е.В., Столяревич Е.С., Виноградова О.В., др. Поражения почек при лимфоплазмоцитарных заболеваниях (обзор литературы и клинические наблюдения). Нефрология и диализ. 2009;11(2):68-94.

The authors declare that there are no conflicts of interest present.