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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">patmedfar</journal-id><journal-title-group><journal-title xml:lang="ru">Пациентоориентированная медицина и фармация</journal-title><trans-title-group xml:lang="en"><trans-title>Patient-Oriented Medicine and Pharmacy</trans-title></trans-title-group></journal-title-group><issn pub-type="epub">2949-1924</issn><publisher><publisher-name>LLC Izdatelstvo OKI</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.37489/2949-1924-0133</article-id><article-id custom-type="edn" pub-id-type="custom">BHSQTQ</article-id><article-id custom-type="elpub" pub-id-type="custom">patmedfar-225</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ФИЗИЧЕСКАЯ И РЕАБИЛИТАЦИОННАЯ МЕДИЦИНА</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>PHYSICAL AND REHABILITATION MEDICINE</subject></subj-group></article-categories><title-group><article-title>Клиническая эффективность иммерсивной виртуальной реальности в медицинской реабилитации: результаты, ограничения и перспективы</article-title><trans-title-group xml:lang="en"><trans-title>Clinical effectiveness of immersive virtual reality in medical rehabilitation: results, limitations and prospects</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-1737-7328</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Плещёв</surname><given-names>И. Е.</given-names></name><name name-style="western" xml:lang="en"><surname>Pleshchev</surname><given-names>I. E.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Плещёв Игорь Евгеньевич — к. м. н., доцент кафедры физической культуры и спорта</p><p>Ярославль</p></bio><bio xml:lang="en"><p>Igor E. Pleshchev — Cand. Sci. (Med.), Associate Professor of the Department of Physical Culture and Sports</p><p>Yaroslavl </p></bio><email xlink:type="simple">doctor.pleshyov@gmail.com</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-4430-2671</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Шишкин</surname><given-names>А. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Shishkin</surname><given-names>A. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Шишкин Алексей Андреевич — к. м. н., доцент кафедры реабилитации, спортивной медицины и физической культуры, старший научный сотрудник НИЛ новейших технологий оздоровительной двигательной активности института профилактической медицины имени З. П. Соловьева</p><p>Москва</p></bio><bio xml:lang="en"><p>Alexey A. Shishkin — Cand. Sci. (Med.), Associate Professor of the Department of Rehabilitation, Sports Medicine and Physical Education, Senior Researcher at the Research Laboratory of New Technologies for Health-Improving Physical Activity, Z. P. Solovyov Institute of Preventive Medicine</p><p>Moscow </p></bio><email xlink:type="simple">doc.shishkin@mail.ru</email><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0009-0005-1043-806X</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Горохов</surname><given-names>И. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Gorokhov</surname><given-names>I. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Горохов Иван Алексеевич — ординатор кафедры травматологии и ортопедии</p><p>Ярославль</p></bio><bio xml:lang="en"><p>Ivan A. Gorokhov — resident of the Department of Traumatology and Orthopedics</p><p>Yaroslavl </p></bio><email xlink:type="simple">goroxov_00@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0009-0001-1576-2548</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Каракчиев</surname><given-names>Д. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Karakchiev</surname><given-names>D. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Каракчиев Дмитрий Андреевич — студент 5 курса института педиатрии и репродуктивного здоровья</p><p>Ярославль</p></bio><bio xml:lang="en"><p>Dmitrii A. Karakchiev — 5th year student of the Institute of Pediatrics and Reproductive Health</p><p>Yaroslavl </p></bio><email xlink:type="simple">dkarakchiev@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>ФГБОУ ВО «Ярославский государственный медицинский университет»</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Yaroslavl State Medical University</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru"><institution>ФГАОУ ВО «Российский национальный исследовательский медицинский университет имени Н.И. Пирогова»</institution><country>Россия</country></aff><aff xml:lang="en"><institution>N.I. Pirogov Russian National Research Medical University</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2026</year></pub-date><pub-date pub-type="epub"><day>30</day><month>03</month><year>2026</year></pub-date><volume>4</volume><issue>1</issue><fpage>77</fpage><lpage>86</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Плещёв И.Е., Шишкин А.А., Горохов И.А., Каракчиев Д.А., 2026</copyright-statement><copyright-year>2026</copyright-year><copyright-holder xml:lang="ru">Плещёв И.Е., Шишкин А.А., Горохов И.А., Каракчиев Д.А.</copyright-holder><copyright-holder xml:lang="en">Pleshchev I.E., Shishkin A.A., Gorokhov I.A., Karakchiev D.A.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.pomph.ru/jour/article/view/225">https://www.pomph.ru/jour/article/view/225</self-uri><abstract><sec><title>Введение</title><p>Введение. Иммерсивная виртуальная реальность (ИВР) рассматривается как перспективный инструмент медицинской реабилитации, однако данные о её клинической эффективности при различных нозологиях требуют систематизации.</p></sec><sec><title>Цель</title><p>Цель. Оценить эффективность ИВР как терапевтического метода восстановления двигательных функций и купирования боли у взрослых пациентов с неврологическими расстройствами (инсульт, болезнь Паркинсона), ампутациями и фибромиалгией.</p></sec><sec><title>Методы</title><p>Методы. Проведён поиск литературы в базах PubMed, Cochrane Library, Scopus за период с 2018 г. по 1 марта 2025 г. Включены исследования с участием лиц старше 18 лет, перенёсших инсульт, страдающих болезнью Паркинсона, фибромиалгией или после ампутации, в которых применялись протоколы с использованием ИВР. Анализировались изменения двигательных функций, болевого синдрома, нейропластичности и приверженности терапии.</p></sec><sec><title>Результаты</title><p>Результаты. ИВР достоверно улучшает силу, ловкость, диапазон движений и координацию у пациентов после инсульта и с болезнью Паркинсона, способствует нейропластичности и снижению боли. У лиц с фибромиалгией отмечено уменьшение кинезиофобии и интенсивности болевого синдрома, у пациентов с ампутациями — улучшение контроля над протезом и мышечной силы. Сеансы ИВР воспринимаются как более приятные и мотивирующие по сравнению с традиционной терапией. Основные ограничения: малый размер выборки, неоднородность протоколов, необходимость присутствия обученного специалиста и недостаточная адаптация для пациентов с тяжёлыми нарушениями.</p></sec><sec><title>Заключение</title><p>Заключение. ИВР является безопасным и эффективным методом реабилитации, однако для стандартизации протоколов, оценки долгосрочных результатов и расширения показаний требуются крупные рандомизированные исследования.</p></sec></abstract><trans-abstract xml:lang="en"><sec><title>Introduction</title><p>Introduction. Immersive virtual reality (IVR) is considered a promising tool for medical rehabilitation, but data on its clinical efficacy across different conditions need to be systematized.</p></sec><sec><title>Objective</title><p>Objective. To evaluate the effectiveness of IVR as a therapeutic method for motor function recovery and pain management in adult patients with neurological disorders (stroke, Parkinson's disease), amputations, and fibromyalgia.</p></sec><sec><title>Methods</title><p>Methods. A literature search was performed in PubMed, Cochrane Library, and Scopus databases from 2018 to March 1, 2025. Studies involving adults after stroke, with Parkinson's disease, fibromyalgia, or limb amputation that used IVR-based protocols were included. Changes in motor functions, pain syndrome, neuroplasticity, and therapy adherence were analyzed.</p></sec><sec><title>Results</title><p>Results. IVR significantly improves strength, dexterity, range of motion, and coordination in post-stroke and Parkinson's disease patients, promotes neuroplasticity, and reduces pain. In fibromyalgia, IVR decreases kinesiophobia and pain intensity; in amputees, it improves prosthetic control and muscle strength. IVR sessions are perceived as more enjoyable and motivating compared to conventional therapy. Main limitations: small sample sizes, heterogeneous protocols, need for a trained specialist, and insufficient adaptation for patients with severe impairments.</p></sec><sec><title>Conclusion</title><p>Conclusion. IVR is a safe and effective rehabilitation method, but large-scale randomized trials are required to standardize protocols, assess long-term outcomes, and expand indications.</p></sec></trans-abstract><kwd-group xml:lang="ru"><kwd>реабилитация</kwd><kwd>иммерсивная виртуальная реальность</kwd><kwd>верхняя конечность</kwd><kwd>инсульт</kwd><kwd>болезнь Паркинсона</kwd><kwd>фибромиалгия</kwd><kwd>ампутация</kwd><kwd>нейропластичность</kwd></kwd-group><kwd-group xml:lang="en"><kwd>rehabilitation</kwd><kwd>immersive virtual reality</kwd><kwd>upper limb</kwd><kwd>stroke</kwd><kwd>pain syndrome</kwd><kwd>Parkinson's disease</kwd><kwd>fibromyalgia</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Capriotti A, Moret S, Del Bello E, et al. Virtual Reality: A New Frontier of Physical Rehabilitation. Sensors (Basel). 2025 May 13;25(10):3080. doi: 10.3390s25103080.</mixed-citation><mixed-citation xml:lang="en">Capriotti A, Moret S, Del Bello E, et al. Virtual Reality: A New Frontier of Physical Rehabilitation. Sensors (Basel). 2025 May 13;25(10):3080. doi: 10.3390s25103080.</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Pournajaf S, Morone G, Goffredo M, et al. Realtà Virtuale Applicata Alla Riabilitazione: Evidenze Cliniche e Prospettive Future. G. Ital. Med. Riabil. 2021;35:30–42.</mixed-citation><mixed-citation xml:lang="en">Pournajaf S, Morone G, Goffredo M, et al. Realtà Virtuale Applicata Alla Riabilitazione: Evidenze Cliniche e Prospettive Future. G. Ital. Med. Riabil. 2021;35:30–42.</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Bourdin P, Martini M, Sanchez-Vives MV. Altered visual feedback from an embodied avatar unconsciously influences movement amplitude and muscle activity. Sci Rep. 2019 Dec 24;9(1):19747. doi: 10.1038/s41598-019-56034-5.</mixed-citation><mixed-citation xml:lang="en">Bourdin P, Martini M, Sanchez-Vives MV. Altered visual feedback from an embodied avatar unconsciously influences movement amplitude and muscle activity. Sci Rep. 2019 Dec 24;9(1):19747. doi: 10.1038/s41598-019-56034-5.</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Kokkinara E, Slater M. Measuring the effects through time of the influence of visuomotor and visuotactile synchronous stimulation on a virtual body ownership illusion. Perception. 2014;43(1):43-58. DOI: 10.1068/p7545.</mixed-citation><mixed-citation xml:lang="en">Kokkinara E, Slater M. Measuring the effects through time of the influence of visuomotor and visuotactile synchronous stimulation on a virtual body ownership illusion. Perception. 2014;43(1):43-58. DOI: 10.1068/p7545.</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Gerig N, Mayo J, Baur K, et al. Missing depth cues in virtual reality limit performance and quality of three dimensional reaching movements. PLoS One. 2018; 13(1):e0189275. doi:10.1371/journal.pone.0189275.</mixed-citation><mixed-citation xml:lang="en">Gerig N, Mayo J, Baur K, et al. Missing depth cues in virtual reality limit performance and quality of three dimensional reaching movements. PLoS One. 2018; 13(1):e0189275. doi:10.1371/journal.pone.0189275.</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Phelan I, Furness PJ, Matsangidou M, et al. Playing your pain away: designing a virtual reality physical therapy for children with upper limb motor impairment. Virtual Real. 2023;27(1):173-185. doi: 10.1007/s10055-021-00522-5.</mixed-citation><mixed-citation xml:lang="en">Phelan I, Furness PJ, Matsangidou M, et al. Playing your pain away: designing a virtual reality physical therapy for children with upper limb motor impairment. Virtual Real. 2023;27(1):173-185. doi: 10.1007/s10055-021-00522-5.</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Hoffman HG, Boe DA, Rombokas E, et al. Virtual reality hand therapy: A new tool for nonopioid analgesia for acute procedural pain, hand rehabilitation, and VR embodiment therapy for phantom limb pain. J Hand Ther. 2020 Apr-Jun;33(2):254-262. doi: 10.1016/j.jht.2020.04.001.</mixed-citation><mixed-citation xml:lang="en">Hoffman HG, Boe DA, Rombokas E, et al. Virtual reality hand therapy: A new tool for nonopioid analgesia for acute procedural pain, hand rehabilitation, and VR embodiment therapy for phantom limb pain. J Hand Ther. 2020 Apr-Jun;33(2):254-262. doi: 10.1016/j.jht.2020.04.001.</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Stanica IC, Moldoveanu F, Portelli GP, Dascalu MI, Moldoveanu A, Ristea MG. Flexible Virtual Reality System for Neurorehabilitation and Quality of Life Improvement. Sensors (Basel). 2020 Oct 23;20(21):6045. doi: 10.3390/s20216045.</mixed-citation><mixed-citation xml:lang="en">Stanica IC, Moldoveanu F, Portelli GP, Dascalu MI, Moldoveanu A, Ristea MG. Flexible Virtual Reality System for Neurorehabilitation and Quality of Life Improvement. Sensors (Basel). 2020 Oct 23;20(21):6045. doi: 10.3390/s20216045.</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Amirthalingam J, Paidi G, Alshowaikh K, et al. Virtual Reality Intervention to Help Improve Motor Function in Patients Undergoing Rehabilitation for Cerebral Palsy, Parkinson's Disease, or Stroke: A Systematic Review of Randomized Controlled Trials. Cureus. 2021 Jul 30;13(7):e16763. doi: 10.7759/cureus.16763.</mixed-citation><mixed-citation xml:lang="en">Amirthalingam J, Paidi G, Alshowaikh K, et al. Virtual Reality Intervention to Help Improve Motor Function in Patients Undergoing Rehabilitation for Cerebral Palsy, Parkinson's Disease, or Stroke: A Systematic Review of Randomized Controlled Trials. Cureus. 2021 Jul 30;13(7):e16763. doi: 10.7759/cureus.16763.</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">Ahmed N, Mauad VAQ, Gomez-Rojas O, et al. The Impact of Rehabilitation-oriented Virtual Reality Device in Patients With Ischemic Stroke in the Early Subacute Recovery Phase: Study Protocol for a Phase III, Single-Blinded, Randomized, Controlled Clinical Trial. J Cent Nerv Syst Dis. 2020 Jan 21;12: 1179573519899471. doi: 10.1177/1179573519899471. Erratum in: J Cent Nerv Syst Dis. 2020 May 15;12: 1179573520923280. doi: 10.1177/1179573520923280.</mixed-citation><mixed-citation xml:lang="en">Ahmed N, Mauad VAQ, Gomez-Rojas O, et al. The Impact of Rehabilitation-oriented Virtual Reality Device in Patients With Ischemic Stroke in the Early Subacute Recovery Phase: Study Protocol for a Phase III, Single-Blinded, Randomized, Controlled Clinical Trial. J Cent Nerv Syst Dis. 2020 Jan 21;12: 1179573519899471. doi: 10.1177/1179573519899471. Erratum in: J Cent Nerv Syst Dis. 2020 May 15;12: 1179573520923280. doi: 10.1177/1179573520923280.</mixed-citation></citation-alternatives></ref><ref id="cit11"><label>11</label><citation-alternatives><mixed-citation xml:lang="ru">Erhardsson M, Alt Murphy M, Sunnerhagen KS. Commercial head-mounted display virtual reality for upper extremity rehabilitation in chronic stroke: a single-case design study. J Neuroeng Rehabil. 2020 Nov 23;17(1):154. doi: 10.1186/s12984-020-00788-x.</mixed-citation><mixed-citation xml:lang="en">Erhardsson M, Alt Murphy M, Sunnerhagen KS. Commercial head-mounted display virtual reality for upper extremity rehabilitation in chronic stroke: a single-case design study. J Neuroeng Rehabil. 2020 Nov 23;17(1):154. doi: 10.1186/s12984-020-00788-x.</mixed-citation></citation-alternatives></ref><ref id="cit12"><label>12</label><citation-alternatives><mixed-citation xml:lang="ru">Mekbib DB, Zhao Z, Wang J, et al. Proactive Motor Functional Recovery Following Immersive Virtual Reality-Based Limb Mirroring Therapy in Patients with Subacute Stroke. Neurotherapeutics. 2020 Oct; 17(4):1919-1930. doi: 10.1007/s13311-020-00882-x.</mixed-citation><mixed-citation xml:lang="en">Mekbib DB, Zhao Z, Wang J, et al. Proactive Motor Functional Recovery Following Immersive Virtual Reality-Based Limb Mirroring Therapy in Patients with Subacute Stroke. Neurotherapeutics. 2020 Oct; 17(4):1919-1930. doi: 10.1007/s13311-020-00882-x.</mixed-citation></citation-alternatives></ref><ref id="cit13"><label>13</label><citation-alternatives><mixed-citation xml:lang="ru">Park W, Kim J, Kim M. Efficacy of virtual reality therapy in ideomotor apraxia rehabilitation: A case report. Medicine (Baltimore). 2021 Jul 16;100(28):e26657. doi: 10.1097/MD.0000000000026657.</mixed-citation><mixed-citation xml:lang="en">Park W, Kim J, Kim M. Efficacy of virtual reality therapy in ideomotor apraxia rehabilitation: A case report. Medicine (Baltimore). 2021 Jul 16;100(28):e26657. doi: 10.1097/MD.0000000000026657.</mixed-citation></citation-alternatives></ref><ref id="cit14"><label>14</label><citation-alternatives><mixed-citation xml:lang="ru">Song YH, Lee HM. Effect of Immersive Virtual Reality-Based Bilateral Arm Training in Patients with Chronic Stroke. Brain Sci. 2021 Aug 3;11(8):1032. doi: 10.3390/brainsci11081032.</mixed-citation><mixed-citation xml:lang="en">Song YH, Lee HM. Effect of Immersive Virtual Reality-Based Bilateral Arm Training in Patients with Chronic Stroke. Brain Sci. 2021 Aug 3;11(8):1032. doi: 10.3390/brainsci11081032.</mixed-citation></citation-alternatives></ref><ref id="cit15"><label>15</label><citation-alternatives><mixed-citation xml:lang="ru">Weber LM, Nilsen DM, Gillen G, et al. Immersive Virtual Reality Mirror Therapy for Upper Limb Recovery After Stroke: A Pilot Study. Am J Phys Med Rehabil. 2019 Sep;98(9):783-788. doi: 10.1097/PHM.0000000000001190.</mixed-citation><mixed-citation xml:lang="en">Weber LM, Nilsen DM, Gillen G, et al. Immersive Virtual Reality Mirror Therapy for Upper Limb Recovery After Stroke: A Pilot Study. Am J Phys Med Rehabil. 2019 Sep;98(9):783-788. doi: 10.1097/PHM.0000000000001190.</mixed-citation></citation-alternatives></ref><ref id="cit16"><label>16</label><citation-alternatives><mixed-citation xml:lang="ru">Mullick AA, Baniña MC, Tomita Y, et al. Obstacle Avoidance and Dual-Tasking During Reaching While Standing in Patients With Mild Chronic Stroke. Neurorehabilitation and Neural Repair. 2021;35(10):915- 928. doi:10.1177/15459683211023190.</mixed-citation><mixed-citation xml:lang="en">Mullick AA, Baniña MC, Tomita Y, et al. Obstacle Avoidance and Dual-Tasking During Reaching While Standing in Patients With Mild Chronic Stroke. Neurorehabilitation and Neural Repair. 2021;35(10):915- 928. doi:10.1177/15459683211023190.</mixed-citation></citation-alternatives></ref><ref id="cit17"><label>17</label><citation-alternatives><mixed-citation xml:lang="ru">Huang CY, Chiang WC, Yeh YC, et al. Effects of virtual reality-based motor control training on inflammation, oxidative stress, neuroplasticity and upper limb motor function in patients with chronic stroke: a randomized controlled trial. BMC Neurol. 2022 Jan 11;22(1):21. doi: 10.1186/s12883-021-02547-4.</mixed-citation><mixed-citation xml:lang="en">Huang CY, Chiang WC, Yeh YC, et al. Effects of virtual reality-based motor control training on inflammation, oxidative stress, neuroplasticity and upper limb motor function in patients with chronic stroke: a randomized controlled trial. BMC Neurol. 2022 Jan 11;22(1):21. doi: 10.1186/s12883-021-02547-4.</mixed-citation></citation-alternatives></ref><ref id="cit18"><label>18</label><citation-alternatives><mixed-citation xml:lang="ru">Schuster-Amft C, Eng K, Suica Z, et al. Effect of a four-week virtual reality-based training versus conventional therapy on upper limb motor function after stroke: A multicenter parallel group randomized trial. PLoS One. 2018 Oct 24;13(10):e0204455. doi: 10.1371/journal.pone.0204455.</mixed-citation><mixed-citation xml:lang="en">Schuster-Amft C, Eng K, Suica Z, et al. Effect of a four-week virtual reality-based training versus conventional therapy on upper limb motor function after stroke: A multicenter parallel group randomized trial. PLoS One. 2018 Oct 24;13(10):e0204455. doi: 10.1371/journal.pone.0204455.</mixed-citation></citation-alternatives></ref><ref id="cit19"><label>19</label><citation-alternatives><mixed-citation xml:lang="ru">Patel J, Fluet G, Qiu Q, et al. Intensive virtual reality and robotic based upper limb training compared to usual care, and associated cortical reorganization, in the acute and early sub-acute periods post-stroke: a feasibility study. J Neuroeng Rehabil. 2019 Jul 17;16(1):92. doi: 10.1186/s12984-019-0563-3.</mixed-citation><mixed-citation xml:lang="en">Patel J, Fluet G, Qiu Q, et al. Intensive virtual reality and robotic based upper limb training compared to usual care, and associated cortical reorganization, in the acute and early sub-acute periods post-stroke: a feasibility study. J Neuroeng Rehabil. 2019 Jul 17;16(1):92. doi: 10.1186/s12984-019-0563-3.</mixed-citation></citation-alternatives></ref><ref id="cit20"><label>20</label><citation-alternatives><mixed-citation xml:lang="ru">Wan C, Zhang Q, Qiu Y, et al. Effects of dual-task mode brain-computer interface based on motor imagery and virtual reality on balance and attention in patients with stroke: a randomized controlled pilot trial. J Neuroeng Rehabil. 2025;22(1):187. doi:10.1186/s12984-025-01730-9.</mixed-citation><mixed-citation xml:lang="en">Wan C, Zhang Q, Qiu Y, et al. Effects of dual-task mode brain-computer interface based on motor imagery and virtual reality on balance and attention in patients with stroke: a randomized controlled pilot trial. J Neuroeng Rehabil. 2025;22(1):187. doi:10.1186/s12984-025-01730-9.</mixed-citation></citation-alternatives></ref><ref id="cit21"><label>21</label><citation-alternatives><mixed-citation xml:lang="ru">Hoolahan K. Exploratory Research on the Gamification of Exercise for Fibromyalgia Using Virtual Reality. International Journal of Virtual Reality; Proceedings of the Virtual Reality International Conference; Virtual. 20–22 April 2019.</mixed-citation><mixed-citation xml:lang="en">Hoolahan K. Exploratory Research on the Gamification of Exercise for Fibromyalgia Using Virtual Reality. International Journal of Virtual Reality; Proceedings of the Virtual Reality International Conference; Virtual. 20–22 April 2019.</mixed-citation></citation-alternatives></ref><ref id="cit22"><label>22</label><citation-alternatives><mixed-citation xml:lang="ru">Sánchez-Herrera-Baeza P, Cano-de-la-Cuerda R, Oña-Simbaña ED, et al. The Impact of a Novel Immersive Virtual Reality Technology Associated with Serious Games in Parkinson's Disease Patients on Upper Limb Rehabilitation: A Mixed Methods Intervention Study. Sensors (Basel). 2020 Apr 11;20(8):2168. doi: 10.3390/s20082168.</mixed-citation><mixed-citation xml:lang="en">Sánchez-Herrera-Baeza P, Cano-de-la-Cuerda R, Oña-Simbaña ED, et al. The Impact of a Novel Immersive Virtual Reality Technology Associated with Serious Games in Parkinson's Disease Patients on Upper Limb Rehabilitation: A Mixed Methods Intervention Study. Sensors (Basel). 2020 Apr 11;20(8):2168. doi: 10.3390/s20082168.</mixed-citation></citation-alternatives></ref><ref id="cit23"><label>23</label><citation-alternatives><mixed-citation xml:lang="ru">Oña ED, Jardón A, Cuesta-Gómez A, et al. Validity of a Fully-Immersive VR-Based Version of the Box and Blocks Test for Upper Limb Function Assessment in Parkinson's Disease. Sensors (Basel). 2020 May 13;20(10):2773. doi: 10.3390/s20102773.</mixed-citation><mixed-citation xml:lang="en">Oña ED, Jardón A, Cuesta-Gómez A, et al. Validity of a Fully-Immersive VR-Based Version of the Box and Blocks Test for Upper Limb Function Assessment in Parkinson's Disease. Sensors (Basel). 2020 May 13;20(10):2773. doi: 10.3390/s20102773.</mixed-citation></citation-alternatives></ref><ref id="cit24"><label>24</label><citation-alternatives><mixed-citation xml:lang="ru">Chen L, Chen Y, Fu WB, et al. The Effect of Virtual Reality on Motor Anticipation and Hand Function in Patients with Subacute Stroke: A Randomized Trial on Movement-Related Potential. Neural Plast. 2022 Jan 24;2022:7399995. doi: 10.1155/2022/7399995.</mixed-citation><mixed-citation xml:lang="en">Chen L, Chen Y, Fu WB, et al. The Effect of Virtual Reality on Motor Anticipation and Hand Function in Patients with Subacute Stroke: A Randomized Trial on Movement-Related Potential. Neural Plast. 2022 Jan 24;2022:7399995. doi: 10.1155/2022/7399995.</mixed-citation></citation-alternatives></ref><ref id="cit25"><label>25</label><citation-alternatives><mixed-citation xml:lang="ru">Gulsen C, Soke F, Eldemir K, et al. Effect of fully immersive virtual reality treatment combined with exercise in fibromyalgia patients: a randomized controlled trial. Assist Technol. 2022 May 4;34(3):256- 263. doi: 10.1080/10400435.2020.1772900.</mixed-citation><mixed-citation xml:lang="en">Gulsen C, Soke F, Eldemir K, et al. Effect of fully immersive virtual reality treatment combined with exercise in fibromyalgia patients: a randomized controlled trial. Assist Technol. 2022 May 4;34(3):256- 263. doi: 10.1080/10400435.2020.1772900.</mixed-citation></citation-alternatives></ref><ref id="cit26"><label>26</label><citation-alternatives><mixed-citation xml:lang="ru">Hashim NA, Abd Razak NA, Gholizadeh H, Abu Osman NA. Video Game-Based Rehabilitation Approach for Individuals Who Have Undergone Upper Limb Amputation: Case-Control Study. JMIR Serious Games. 2021 Feb 4;9(1):e17017. doi: 10.2196/17017.</mixed-citation><mixed-citation xml:lang="en">Hashim NA, Abd Razak NA, Gholizadeh H, Abu Osman NA. Video Game-Based Rehabilitation Approach for Individuals Who Have Undergone Upper Limb Amputation: Case-Control Study. JMIR Serious Games. 2021 Feb 4;9(1):e17017. doi: 10.2196/17017.</mixed-citation></citation-alternatives></ref><ref id="cit27"><label>27</label><citation-alternatives><mixed-citation xml:lang="ru">Salatino A, Zavattaro C, Gammeri R, et al. Virtual reality rehabilitation for unilateral spatial neglect: A systematic review of immersive, semi-immersive and non-immersive techniques. Neuroscience and Biobehavioral Reviews. 2023 Sep;152:105248. DOI: 10.1016/j.neubiorev.2023.105248.</mixed-citation><mixed-citation xml:lang="en">Salatino A, Zavattaro C, Gammeri R, et al. Virtual reality rehabilitation for unilateral spatial neglect: A systematic review of immersive, semi-immersive and non-immersive techniques. Neuroscience and Biobehavioral Reviews. 2023 Sep;152:105248. DOI: 10.1016/j.neubiorev.2023.105248.</mixed-citation></citation-alternatives></ref><ref id="cit28"><label>28</label><citation-alternatives><mixed-citation xml:lang="ru">Tuck N, Pollard C, Good C, et al. Active Virtual Reality for Chronic Primary Pain: Mixed Methods Randomized Pilot Study. JMIR Form Res. 2022 Jul 13;6(7):e38366. doi: 10.2196/38366.</mixed-citation><mixed-citation xml:lang="en">Tuck N, Pollard C, Good C, et al. Active Virtual Reality for Chronic Primary Pain: Mixed Methods Randomized Pilot Study. JMIR Form Res. 2022 Jul 13;6(7):e38366. doi: 10.2196/38366.</mixed-citation></citation-alternatives></ref><ref id="cit29"><label>29</label><citation-alternatives><mixed-citation xml:lang="ru">Белова А.Н., Шабанова М.А., Сушин В.О., и др. Кинезиофобия у пациентов, нуждающихся в эндопротезировании тазобедренного и коленного суставов: выраженность и провоцирующие факторы. Вопросы курортологии, физиотерапии и лечебной физической культуры. 2022;99(6):34‑41. doi: 10.17116/kurort20229906134</mixed-citation><mixed-citation xml:lang="en">Belova AN, Shabanova MA, Sushin VO, et al. Kinesiophobia in patients requiring hip and knee endoprosthetics: severity and provoking factors. Problems of Balneology, Physiotherapy and Exercise Therapy. 2022;99(6):34‑41. doi: 10.17116/kurort20229906134 (In Russ.)</mixed-citation></citation-alternatives></ref><ref id="cit30"><label>30</label><citation-alternatives><mixed-citation xml:lang="ru">Darnall BD, Krishnamurthy P, Tsuei J, Minor JD. Self-Administered Skills-Based Virtual Reality Intervention for Chronic Pain: Randomized Controlled Pilot Study. JMIR Form Res. 2020 Jul 7;4(7):e17293. doi: 10.2196/17293.</mixed-citation><mixed-citation xml:lang="en">Darnall BD, Krishnamurthy P, Tsuei J, Minor JD. Self-Administered Skills-Based Virtual Reality Intervention for Chronic Pain: Randomized Controlled Pilot Study. JMIR Form Res. 2020 Jul 7;4(7):e17293. doi: 10.2196/17293.</mixed-citation></citation-alternatives></ref><ref id="cit31"><label>31</label><citation-alternatives><mixed-citation xml:lang="ru">Плещёв И.Е., Николенко В.Н., Ачкасов Е.Е., и др. Влияние физических упражнений и нутритивной поддержки на пациентов пожилого и старческого возраста с саркопеническим ожирением. Acta Biomedica Scientifica. 2024;9(3):14-25. Doi: 10.29413/ABS.2024-9.3.2</mixed-citation><mixed-citation xml:lang="en">Pleshchev I.E., Nikolenko V.N., Achkasov E.E., et al. The effect of exercise and nutritional support on elderly and senile patients with sarcopenic obesity. Acta Biomedica Scientifica. 2024;9(3):14-25. Doi: 10.29413/ABS.2024-9.3.2.</mixed-citation></citation-alternatives></ref><ref id="cit32"><label>32</label><citation-alternatives><mixed-citation xml:lang="ru">Christensen SWM, Almsborg H, M, Vain TS, et al. The Effect of Virtual Reality on Cold Pain Sensitivity in Patients with Fibromyalgia and Pain-Free Individuals: A Randomized Crossover Study. Games Health J. 2023 Aug;12(4):295-301. doi: 10.1089/g4h.2022.0138.</mixed-citation><mixed-citation xml:lang="en">Christensen SWM, Almsborg H, M, Vain TS, et al. The Effect of Virtual Reality on Cold Pain Sensitivity in Patients with Fibromyalgia and Pain-Free Individuals: A Randomized Crossover Study. Games Health J. 2023 Aug;12(4):295-301. doi: 10.1089/g4h.2022.0138.</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
