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<article article-type="review-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">patmedfar</journal-id><journal-title-group><journal-title xml:lang="ru">Пациентоориентированная медицина и фармация</journal-title><trans-title-group xml:lang="en"><trans-title>Patient-Oriented Medicine and Pharmacy</trans-title></trans-title-group></journal-title-group><issn pub-type="epub">2949-1924</issn><publisher><publisher-name>LLC Izdatelstvo OKI</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.37489/2949-1924-0081</article-id><article-id custom-type="edn" pub-id-type="custom">VTUIXK</article-id><article-id custom-type="elpub" pub-id-type="custom">patmedfar-141</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>РЕВМАТОЛОГИЯ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>RHEUMATOLOGY</subject></subj-group></article-categories><title-group><article-title>Оценка активности иммуновоспалительного процесса при ревматоидном артрите – клинические индексы и лабораторные маркеры: влияние инфекции COVID-19</article-title><trans-title-group xml:lang="en"><trans-title>Clinical indices and laboratory markers for evaluating the immune-mediated inflammation in rheumatoid arthritis: the impact of COVID-19</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0009-0000-6641-7544</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Коновалов</surname><given-names>К. М.</given-names></name><name name-style="western" xml:lang="en"><surname>Konovalov</surname><given-names>K. M.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Коновалов Кирилл Михайлович — аспирант кафедры поликлинической терапии, клинической лабораторной диагностики и медицинской биохимии.</p><p>Ярославль</p></bio><bio xml:lang="en"><p>Kirill M. Konovalov — Postgraduate of the Department of Polyclinic Therapy, Clinical Laboratory Diagnostics and Medical Biochemistry.</p><p>Yaroslavl</p></bio><email xlink:type="simple">k.koshkasa@gmail.com</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-7847-1679</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Баранов</surname><given-names>А. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Baranov</surname><given-names>A. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Баранов Андрей Анатольевич — д. м. н., профессор, зав. кафедрой поликлинической терапии, клинической, лабораторной диагностики и медицинской биохимии.</p><p>Ярославль</p></bio><bio xml:lang="en"><p>Andrey A. Baranov — Dr. Sci. (Med.), professor, Head of the Department of the Department of Polyclinic Therapy, Clinical Laboratory Diagnostics and Medical Biochemistry.</p><p>Yaroslavl</p></bio><email xlink:type="simple">bara_aa@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-2692-399X</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Лапкина</surname><given-names>Н. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Lapkina</surname><given-names>N. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Лапкина Наталья Александровна — к. м. н., доцент кафедры поликлинической терапии, клинической лабораторной диагностики и медицинской биохимии.</p><p>Ярославль</p></bio><bio xml:lang="en"><p>Natalia A. Lapkina — Cand. Sci. (Med.), Associate professor at Department of Polyclinic Therapy, Clinical Laboratory Diagnostics and Medical Biochemistry.</p><p>Yaroslavl</p></bio><email xlink:type="simple">lanaal@rambler.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-8846-0401</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Абайтова</surname><given-names>Н. Е.</given-names></name><name name-style="western" xml:lang="en"><surname>Abaytova</surname><given-names>N. E.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Абайтова Наталья Евгеньевна — к. м. н., доцент кафедры поликлинической терапии, клинической лабораторной диагностики и медицинской биохимии.</p><p>Ярославль</p></bio><bio xml:lang="en"><p>Natalia E. Abaytova — Cand. Sci. (Med.), Associate professor at Department of Polyclinic Therapy, Clinical Laboratory Diagnostics and Medical Biochemistry.</p><p>Yaroslavl</p></bio><email xlink:type="simple">nabaitova1922@yandex.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0009-0000-1247-1000</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Борисова</surname><given-names>О. Л.</given-names></name><name name-style="western" xml:lang="en"><surname>Borisova</surname><given-names>O. L.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Борисова Ольга Львовна — к. б. н., ассистент кафедры поликлинической терапии, клинической лабораторной диагностики и медицинской биохимии.</p><p>Ярославль</p></bio><bio xml:lang="en"><p>Olga L. Borisova — Candidate of Biological Sciences, Assistant of Department of Polyclinic Therapy, Clinical Laboratory Diagnostics and Medical Biochemistry.</p><p>Yaroslavl</p></bio><email xlink:type="simple">oligabl67@gmail.com</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>ФГБОУ ВО «Ярославский государственный медицинский университет»</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Yaroslavl State Medical University</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2025</year></pub-date><pub-date pub-type="epub"><day>24</day><month>03</month><year>2025</year></pub-date><volume>3</volume><issue>1</issue><fpage>49</fpage><lpage>58</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Коновалов К.М., Баранов А.А., Лапкина Н.А., Абайтова Н.Е., Борисова О.Л., 2025</copyright-statement><copyright-year>2025</copyright-year><copyright-holder xml:lang="ru">Коновалов К.М., Баранов А.А., Лапкина Н.А., Абайтова Н.Е., Борисова О.Л.</copyright-holder><copyright-holder xml:lang="en">Konovalov K.M., Baranov A.A., Lapkina N.A., Abaytova N.E., Borisova O.L.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.pomph.ru/jour/article/view/141">https://www.pomph.ru/jour/article/view/141</self-uri><abstract><p>Ревматоидный артрит (РА) — иммуновоспалительное ревматическое заболевание неизвестной этиологии, представляющее существенное бремя для пациентов и для системы здравоохранения. Контроль воспаления при РА определяет прогноз заболевания, и достижение ремиссии или низкой активности заболевания является приоритетной задачей для практикующего специалиста. Оценка эффективности текущей схемы лечения РА у конкретного пациента зависит от величины индексов активности и динамики их изменения. Используемые в рутинной современной клинической практике индексы активности РА являются плодом кропотливого полувекового поиска оптимального набора клинических, лабораторных и инструментальных параметров, наиболее полно отражающих подлежащие патогенетические механизмы воспаления при РА. Не вошедшие в эти индексы рутинные показатели анализа крови могут являться ценным дополнением картины заболевания. Новая коронавирусная инфекция COVID-19, имеет сходные патогенетические механизмы с иммуновоспалительными ревматическими заболеваниями, а её клинические и лабораторные последствия в виде постковид-19-синдрома, затрудняют оценку активности РА с использованием существующих индексов активности, ставят вопрос о необходимости принимать их во внимание при оценке эффективности и выборе тактики лечения пациента с РА.</p></abstract><trans-abstract xml:lang="en"><p>Rheumatoid arthritis (RA) is an immune-mediated inflammatory disease of unknown etiology that represents a considerable burden for both the patient and the healthcare system. The degree to which inflammation is being controlled determines the prognosis; therefore, achieving remission or low disease activity is of paramount importance to medical practitioners. The effectiveness of the currently employed treatment regimen for a specific patient is determined by the disease activity indices and the change in their values during treatment. The commonly used RA disease activity indices are the result of a painstaking search for the optimal set of clinical, laboratory and instrumental parameters reflecting the underlying pathogenesis of inflammation in RA spanning half a century. Routine laboratory tests not included in these indices can nevertheless provide additional valuable information regarding the disease. The new coronavirus infection, COVID-19, has similar pathogenetic mechanisms with immunoinflammatory rheumatic diseases, and its clinical and laboratory consequences in the form of postcovid-19 syndrome, make it difficult to assess the activity of RA using existing activity indices, raise the question of the need to take them into account when assessing the effectiveness and choosing the tactics of treatment of a patient with RA.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>ревматоидный артрит</kwd><kwd>COVID-19</kwd><kwd>активность заболевания</kwd></kwd-group><kwd-group xml:lang="en"><kwd>rheumatoid arthritis</kwd><kwd>COVID-19</kwd><kwd>disease activity</kwd></kwd-group><funding-group><funding-statement xml:lang="ru">Работа выполнялась без спонсорской поддержки</funding-statement><funding-statement xml:lang="en">The work was carried out without sponsorship</funding-statement></funding-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Насонов Е.Л., Лила А.М. 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